Microbiology

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FtsZ

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Microbiology

Definition

FtsZ is a protein that assembles into a ring at the future site of the septum in bacterial cell division. It is functionally analogous to tubulin in eukaryotes and is essential for cytokinesis.

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5 Must Know Facts For Your Next Test

  1. FtsZ polymerizes to form a Z-ring at the midpoint of the cell, guiding the division process.
  2. It recruits other proteins involved in cell wall synthesis and septation.
  3. FtsZ is regulated by several proteins to ensure proper timing and positioning of cell division.
  4. The GTPase activity of FtsZ provides the energy required for its polymerization and depolymerization cycles.
  5. Mutations or inhibitors targeting FtsZ can disrupt bacterial cell division, making it a potential target for new antibiotics.

Review Questions

  • What role does FtsZ play in bacterial cell division?
  • How does FtsZ contribute to the formation of the septum during cytokinesis?
  • Why is FtsZ considered a potential target for antibiotic development?
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