Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025
Definition
Girolamo Fracastoro was an Italian physician and scholar who proposed that diseases were caused by transferable seed-like entities. His work laid the foundation for the germ theory of disease.
Fracastoro's most famous work is 'De Contagione et Contagiosis Morbis,' published in 1546, where he articulated his ideas about contagion.
He suggested that diseases like syphilis were transmitted by direct contact, through the air, or via contaminated objects.
Fracastoro's concept of 'seminaria' (seeds of disease) predated the discovery of microorganisms but was a significant step towards understanding infectious diseases.
His ideas influenced later scientists, including Louis Pasteur and Robert Koch, who provided experimental evidence for germ theory.
Fracastoro also described typhus and differentiated it from other febrile illnesses.