Endotoxin is a component of the outer membrane of Gram-negative bacteria, primarily composed of lipopolysaccharides (LPS). It can trigger strong immune responses when released into the host organism.
5 Must Know Facts For Your Next Test
Endotoxins are heat-stable and not destroyed by standard sterilization processes.
They are released mainly when bacterial cells die and disintegrate.
High concentrations of endotoxins can cause septic shock, characterized by fever, hypotension, and multi-organ failure.
The lipid A portion of the LPS is responsible for the toxic effects associated with endotoxins.
Detecting endotoxins in medical devices and pharmaceuticals is crucial to prevent adverse reactions in patients.
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Related terms
Exotoxin: A toxin released by bacteria into the surrounding environment that has highly specific targets.