Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Double-stranded DNA (dsDNA) consists of two complementary strands that form the double helix structure of DNA. It is the genetic material for many organisms, including some viruses.
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dsDNA has two antiparallel strands held together by hydrogen bonds between complementary base pairs (adenine-thymine and cytosine-guanine).
Many viruses use dsDNA as their genetic material, including bacteriophages and herpesviruses.
In the viral life cycle, dsDNA can be either linear or circular depending on the virus type.
The replication of dsDNA involves enzymes like DNA polymerase which ensure accurate copying of the genetic material.
Mutations in dsDNA can lead to changes in protein function and are a major source of genetic variation.