Dosage

Definition

Dosage is the amount and frequency of a drug administered to achieve the desired therapeutic effect. It is critical in determining the efficacy and safety of antimicrobial treatments.

5 Must Know Facts For Your Next Test

1. Dosage must be calculated based on factors such as patient weight, age, kidney function, and severity of infection.
2. Underdosing can lead to ineffective treatment and development of antibiotic resistance.
3. Overdosing may result in toxicity and adverse side effects.
4. The Minimum Inhibitory Concentration (MIC) helps determine the appropriate dosage for antimicrobial drugs.
5. Adjustments in dosage are often necessary for patients with renal or liver impairments.

Review Questions

• What factors influence the calculation of an appropriate antimicrobial drug dosage?
• Why is it important to avoid underdosing when administering antimicrobials?
• How does the Minimum Inhibitory Concentration (MIC) relate to determining dosage?

Related terms

Minimum Inhibitory Concentration (MIC):

The lowest concentration of an antimicrobial that will inhibit the visible growth of a microorganism after overnight incubation.

Therapeutic Index: A ratio comparing the toxic dose to the therapeutic dose of a drug, indicating its safety margin.

Pharmacokinetics:

The study of how a drug is absorbed, distributed, metabolized, and excreted by the body.