Microbiology

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Deletion

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Microbiology

Definition

Deletion is a type of genetic mutation where one or more nucleotides are removed from the DNA sequence. This can lead to frameshift mutations and potential loss of gene function.

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5 Must Know Facts For Your Next Test

  1. Deletions can vary in size from a single nucleotide to large sections of chromosomes.
  2. Small deletions may affect only a single gene, while large deletions can impact multiple genes or regulatory regions.
  3. Frameshift mutations caused by deletions often result in nonfunctional proteins due to altered reading frames.
  4. Deletions are typically identified through techniques such as PCR, sequencing, or comparative genomic hybridization.
  5. Deletions can be spontaneous or induced by mutagens like radiation or chemicals.

Review Questions

  • What is the primary consequence of a deletion mutation?
  • How do small and large deletions differ in their genetic impact?
  • What methods are commonly used to detect deletion mutations?
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