Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
A cytokine storm is an excessive and uncontrolled release of pro-inflammatory cytokines, often resulting from an overactive immune response. It can lead to severe inflammation and tissue damage, particularly in the respiratory system.
5 Must Know Facts For Your Next Test
Cytokine storms are associated with severe viral infections such as influenza and COVID-19.
They can result in acute respiratory distress syndrome (ARDS) due to extreme inflammation in the lungs.
Cytokine storms involve key cytokines like interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).
Immunosuppressive treatments like corticosteroids are sometimes used to manage cytokine storms.
Early detection and intervention are crucial for reducing morbidity and mortality associated with cytokine storms.
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Related terms
Interleukin-6 (IL-6): A pro-inflammatory cytokine often elevated during a cytokine storm.
Acute Respiratory Distress Syndrome (ARDS): A severe lung condition that can be triggered by a cytokine storm.
Tumor Necrosis Factor-alpha (TNF-alpha): A key inflammatory mediator involved in the development of a cytokine storm.