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Cross-linkage

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Cross-linkage refers to the binding of multiple antigens by a single antibody, resulting in the formation of a complex. This process is crucial for the activation and effectiveness of the immune response.

5 Must Know Facts For Your Next Test

  1. Cross-linkage occurs when a single antibody binds to multiple epitopes on different antigens.
  2. It enhances the phagocytosis of pathogens by forming larger antigen-antibody complexes.
  3. B cells use cross-linkage as part of their mechanism to recognize and neutralize pathogens.
  4. The process can lead to agglutination, making it easier for immune cells to identify and eliminate pathogens.
  5. Cross-linkage is essential for effective humoral immunity, aiding in the clearance of extracellular pathogens.

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