Continuous cell line

Definition

A continuous cell line is a population of cells from a single origin that can be maintained in vitro for an indefinite number of generations. These cells are often used in research to study viruses and other pathogens.

5 Must Know Facts For Your Next Test

1. Continuous cell lines are derived from cancerous cells or cells that have undergone mutations allowing them to proliferate indefinitely.
2. They are crucial for the isolation, culture, and identification of various viruses.
3. Unlike primary cell lines, continuous cell lines do not have a limited lifespan.
4. Common examples include HeLa cells and Vero cells, which are frequently used in virology.
5. Continuous cell lines can sometimes exhibit genetic instability over long periods, potentially affecting experimental outcomes.

Review Questions

• What is the primary advantage of using continuous cell lines in virology research?
• How do continuous cell lines differ from primary cell lines?
• Name two commonly used continuous cell lines in microbiology studies.

Related terms

Primary Cell Line: A population of cells taken directly from living tissue and maintained for growth in vitro but with a limited lifespan.

HeLa Cells: A widely used continuous cell line derived from cervical cancer cells.

Vero Cells: A continuous cell line derived from kidney epithelial cells of African green monkeys, often used for virus cultivation.