Microbiology

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Cidofovir

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Microbiology

Definition

Cidofovir is an antiviral medication used primarily to treat cytomegalovirus (CMV) infections, particularly in immunocompromised patients. It works by inhibiting viral DNA polymerase, preventing viral replication.

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5 Must Know Facts For Your Next Test

  1. Cidofovir is effective against a range of double-stranded DNA viruses, including CMV and some types of herpesviruses.
  2. It is often used to treat CMV retinitis in patients with AIDS.
  3. Cidofovir requires phosphorylation to become active and exert its antiviral effects.
  4. The drug can cause nephrotoxicity, so it is usually administered with probenecid and intravenous saline hydration to reduce kidney damage.
  5. It has been investigated for potential use against other viruses like HPV and adenovirus.

Review Questions

  • What type of infections is cidofovir primarily used to treat?
  • How does cidofovir inhibit viral replication?
  • What are common side effects associated with cidofovir administration?

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