Cidofovir

Definition

Cidofovir is an antiviral medication used primarily to treat cytomegalovirus (CMV) infections, particularly in immunocompromised patients. It works by inhibiting viral DNA polymerase, preventing viral replication.

5 Must Know Facts For Your Next Test

1. Cidofovir is effective against a range of double-stranded DNA viruses, including CMV and some types of herpesviruses.
2. It is often used to treat CMV retinitis in patients with AIDS.
3. Cidofovir requires phosphorylation to become active and exert its antiviral effects.
4. The drug can cause nephrotoxicity, so it is usually administered with probenecid and intravenous saline hydration to reduce kidney damage.
5. It has been investigated for potential use against other viruses like HPV and adenovirus.

Review Questions

Related terms

cytomegalovirus (CMV):

A type of herpesvirus that can cause severe disease in immunocompromised individuals.

antiviral: A medication or treatment designed to combat viral infections.

nephrotoxicity:

Kidney damage caused by exposure to harmful substances, including certain medications.