Chronic myelogenous leukemia (CML) is a type of cancer that originates in the bone marrow and leads to the overproduction of white blood cells. It is characterized by the presence of the Philadelphia chromosome, a genetic abnormality.
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CML primarily affects adults and is rare in children.
The disease progresses through three phases: chronic, accelerated, and blast crisis.
The Philadelphia chromosome results from a translocation between chromosomes 9 and 22.
Tyrosine kinase inhibitors (TKIs) are commonly used for treatment and can induce remission in many patients.
Symptoms may include fatigue, weight loss, night sweats, and an enlarged spleen.
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Related terms
Philadelphia Chromosome: A specific genetic abnormality involving a translocation between chromosomes 9 and 22.
Tyrosine Kinase Inhibitors (TKIs): A class of drugs that block enzymes involved in cell signaling and are used to treat certain cancers.
Bone Marrow: The spongy tissue inside bones where blood cells are produced.