๐Ÿฆ microbiology review

key term - Chronic myelogenous leukemia

Definition

Chronic myelogenous leukemia (CML) is a type of cancer that originates in the bone marrow and leads to the overproduction of white blood cells. It is characterized by the presence of the Philadelphia chromosome, a genetic abnormality.

5 Must Know Facts For Your Next Test

  1. CML primarily affects adults and is rare in children.
  2. The disease progresses through three phases: chronic, accelerated, and blast crisis.
  3. The Philadelphia chromosome results from a translocation between chromosomes 9 and 22.
  4. Tyrosine kinase inhibitors (TKIs) are commonly used for treatment and can induce remission in many patients.
  5. Symptoms may include fatigue, weight loss, night sweats, and an enlarged spleen.

Review Questions

"Chronic myelogenous leukemia" also found in: