Chromatin remodeling involves the dynamic modification of chromatin architecture to allow access to condensed genomic DNA. This process is crucial for regulating gene expression, DNA replication, and repair.
5 Must Know Facts For Your Next Test
Chromatin remodeling is essential for facilitating or restricting access to DNA by transcription factors and other proteins.
It often involves ATP-dependent chromatin remodeling complexes that reposition nucleosomes.
Post-translational modifications such as acetylation, methylation, and phosphorylation of histones play a significant role in chromatin remodeling.
The SWI/SNF complex is a well-studied example of an ATP-dependent chromatin remodeling complex.
Aberrations in chromatin remodeling mechanisms can lead to various diseases, including cancer.