Ceftazidime

Definition

Ceftazidime is a third-generation cephalosporin antibiotic used to treat severe bacterial infections by inhibiting cell wall synthesis. It is particularly effective against Gram-negative bacteria, including Pseudomonas aeruginosa.

5 Must Know Facts For Your Next Test

1. Ceftazidime works by binding to penicillin-binding proteins (PBPs), disrupting the synthesis of the bacterial cell wall.
2. It is especially effective against Gram-negative bacteria and is often used in hospital settings for serious infections.
3. Ceftazidime can be administered intravenously or intramuscularly.
4. Resistance to ceftazidime can occur via the production of beta-lactamases, which hydrolyze the antibiotic.
5. It is commonly used in patients with cystic fibrosis who are prone to Pseudomonas aeruginosa lung infections.

Related terms

Cephalosporins:

A class of antibiotics that work by inhibiting cell wall synthesis and are divided into several generations based on their spectrum of activity.

Beta-lactamases: Enzymes produced by some bacteria that provide resistance by breaking down beta-lactam antibiotics like ceftazidime.

Penicillin-binding proteins (PBPs): A group of proteins that are targeted by beta-lactam antibiotics, crucial for bacterial cell wall synthesis.