Bridge reaction

Definition

The bridge reaction is a critical step in cellular respiration that connects glycolysis to the Krebs cycle. It involves the conversion of pyruvate into acetyl-CoA, releasing CO2 and generating NADH.

5 Must Know Facts For Your Next Test

1. The bridge reaction occurs in the mitochondrial matrix in eukaryotes.
2. It converts two molecules of pyruvate (from one glucose) into two molecules of acetyl-CoA.
3. CO2 is released as a byproduct during this reaction.
4. NAD+ is reduced to NADH during the conversion process.
5. The enzyme complex responsible for this reaction is called Pyruvate Dehydrogenase Complex (PDC).

Review Questions

Related terms

Glycolysis:

The metabolic pathway that breaks down glucose into pyruvate, producing ATP and NADH.

Krebs Cycle:

A series of chemical reactions used by all aerobic organisms to generate energy through oxidation of acetyl-CoA.

Pyruvate Dehydrogenase Complex (PDC): An enzyme complex that catalyzes the conversion of pyruvate into acetyl-CoA.