Bradykinin

Definition

Bradykinin is a peptide that causes blood vessels to dilate (enlarge), leading to increased permeability and allowing immune cells to access affected tissues. It plays a crucial role in inflammation and pain signaling.

5 Must Know Facts For Your Next Test

1. Bradykinin is produced through the kinin-kallikrein system, especially during tissue injury or inflammation.
2. It increases vascular permeability, which helps immune cells reach infected or damaged tissues.
3. Bradykinin contributes to the symptoms of inflammation, such as redness, heat, swelling, and pain.
4. It can induce smooth muscle contraction and influence blood pressure regulation.
5. The effects of bradykinin are mediated by B1 and B2 receptors on cell surfaces.

Related terms

Kinin-Kallikrein System: A complex proteolytic cascade responsible for producing kinins like bradykinin.

Vascular Permeability: The ability of blood vessel walls to allow the passage of substances into and out of the bloodstream.

B2 Receptor: A receptor that primarily mediates most of the physiological effects of bradykinin.