key term - Autoimmune polyendocrine syndromes (APS)
Definition
Autoimmune polyendocrine syndromes (APS) are a group of rare disorders characterized by the immune system attacking multiple endocrine glands. This can lead to various hormonal imbalances and associated diseases.
5 Must Know Facts For Your Next Test
- APS is classified into APS-1 and APS-2 based on the specific endocrine glands affected and genetic factors.
- APS-1 typically manifests in childhood, while APS-2 generally appears in adulthood.
- Common organs affected include the thyroid, adrenal glands, and pancreas.
- Genetic mutations in the AIRE gene are linked to APS-1, while HLA genes are implicated in APS-2.
- Diagnosis often involves identifying characteristic clinical features and confirming through genetic testing or antibody screening.
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