APCs

Definition

Antigen-presenting cells (APCs) are immune cells that capture, process, and present antigens to T lymphocytes, initiating an adaptive immune response. Key APCs include dendritic cells, macrophages, and B cells.

5 Must Know Facts For Your Next Test

1. APCs display antigens on their surface using major histocompatibility complex (MHC) molecules.
2. Dendritic cells are considered the most potent APCs for activating naïve T cells.
3. Macrophages can act as APCs but also play a critical role in phagocytosis and pathogen destruction.
4. B cells can present antigens to helper T cells via MHC class II molecules.
5. Interaction between APCs and T lymphocytes is crucial for the activation and proliferation of adaptive immune responses.

Review Questions

Related terms

T Lymphocytes:

A type of white blood cell essential for cell-mediated immunity.

Major Histocompatibility Complex (MHC):

A set of cell surface proteins important for antigen presentation to T cells.

Adaptive Immunity:

The part of the immune system that adapts its response to specific pathogens through memory formation.