Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Anti-AChR antibodies are autoantibodies directed against acetylcholine receptors on the neuromuscular junction. They play a crucial role in the pathogenesis of myasthenia gravis by impairing neuromuscular transmission.
5 Must Know Facts For Your Next Test
Anti-AChR antibodies bind to acetylcholine receptors, leading to their degradation and reduced muscle contraction.
The presence of anti-AChR antibodies is a key diagnostic marker for myasthenia gravis.
These antibodies can be detected through blood tests such as radioimmunoassay or enzyme-linked immunosorbent assay (ELISA).
Approximately 85% of patients with generalized myasthenia gravis test positive for anti-AChR antibodies.
Treatment strategies for myasthenia gravis may include immunosuppressive drugs, plasmapheresis, and thymectomy.
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Related terms
Myasthenia Gravis: An autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles due to impaired communication between nerves and muscles.
Neuromuscular Junction: The synapse or connection between a motor neuron and a muscle fiber where nerve impulses transmit signals to initiate muscle contraction.
Immunosuppressive Drugs: Medications that inhibit or prevent activity of the immune system, commonly used in treating autoimmune diseases like myasthenia gravis.