๐Ÿฆ microbiology review

key term - Anti-AChR antibodies

Definition

Anti-AChR antibodies are autoantibodies directed against acetylcholine receptors on the neuromuscular junction. They play a crucial role in the pathogenesis of myasthenia gravis by impairing neuromuscular transmission.

5 Must Know Facts For Your Next Test

  1. Anti-AChR antibodies bind to acetylcholine receptors, leading to their degradation and reduced muscle contraction.
  2. The presence of anti-AChR antibodies is a key diagnostic marker for myasthenia gravis.
  3. These antibodies can be detected through blood tests such as radioimmunoassay or enzyme-linked immunosorbent assay (ELISA).
  4. Approximately 85% of patients with generalized myasthenia gravis test positive for anti-AChR antibodies.
  5. Treatment strategies for myasthenia gravis may include immunosuppressive drugs, plasmapheresis, and thymectomy.

Review Questions

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