key term - Anti-AChR antibodies

Definition

Anti-AChR antibodies are autoantibodies directed against acetylcholine receptors on the neuromuscular junction. They play a crucial role in the pathogenesis of myasthenia gravis by impairing neuromuscular transmission.

5 Must Know Facts For Your Next Test

1. Anti-AChR antibodies bind to acetylcholine receptors, leading to their degradation and reduced muscle contraction.
2. The presence of anti-AChR antibodies is a key diagnostic marker for myasthenia gravis.
3. These antibodies can be detected through blood tests such as radioimmunoassay or enzyme-linked immunosorbent assay (ELISA).
4. Approximately 85% of patients with generalized myasthenia gravis test positive for anti-AChR antibodies.
5. Treatment strategies for myasthenia gravis may include immunosuppressive drugs, plasmapheresis, and thymectomy.

Review Questions

Related terms

Myasthenia Gravis: An autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles due to impaired communication between nerves and muscles.

Neuromuscular Junction: The synapse or connection between a motor neuron and a muscle fiber where nerve impulses transmit signals to initiate muscle contraction.

Immunosuppressive Drugs: Medications that inhibit or prevent activity of the immune system, commonly used in treating autoimmune diseases like myasthenia gravis.