Angioedema

Definition

Angioedema is a rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It is often caused by an allergic reaction or a hypersensitivity response.

5 Must Know Facts For Your Next Test

1. Angioedema commonly results from histamine release due to an IgE-mediated hypersensitivity reaction.
2. It can be triggered by allergens such as foods, medications, insect stings, and latex.
3. The condition may present with swelling in areas like the face, lips, throat, and extremities.
4. Treatment often involves antihistamines, corticosteroids, and in severe cases, epinephrine.
5. Hereditary angioedema is a rare form that is not triggered by allergens but by genetic mutations affecting C1 inhibitor protein.

Review Questions

• What are common triggers for angioedema?
• Which type of hypersensitivity reaction is associated with angioedema?
• What are the primary treatments for managing angioedema?

Related terms

Urticaria: A skin rash characterized by red, itchy welts that may occur alongside angioedema.

Anaphylaxis:

A severe, potentially life-threatening allergic reaction that can include symptoms of angioedema.

Histamine:

A compound released by mast cells during an allergic reaction that contributes to symptoms like swelling in angioedema.