Addison disease is a rare autoimmune disorder where the adrenal glands do not produce enough steroid hormones, particularly cortisol and aldosterone. This can lead to severe fatigue, muscle weakness, and low blood pressure.
5 Must Know Facts For Your Next Test
Addison disease results from the immune system attacking the adrenal cortex.
Symptoms include hyperpigmentation of the skin, weight loss, and salt cravings.
Diagnosis often involves blood tests showing low cortisol levels and high ACTH levels.
Treatment usually includes hormone replacement therapy with glucocorticoids and mineralocorticoids.
Patients with Addison disease are at risk of an Addisonian crisis, which is a life-threatening emergency requiring immediate medical attention.
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Related terms
Autoimmune Disorder: A condition in which the immune system attacks the body's own tissues.
Adrenal Glands: Small glands located on top of each kidney that produce hormones such as cortisol and aldosterone.
Glucocorticoids: A class of corticosteroids involved in metabolism regulation and immune response suppression.