Activation of B cells

Definition

Activation of B cells is the process by which B lymphocytes recognize an antigen, leading to their proliferation and differentiation into plasma cells that produce antibodies. This activation is crucial for the humoral immune response.

5 Must Know Facts For Your Next Test

1. B cells are activated when their B cell receptor (BCR) binds to a specific antigen.
2. T-helper cells provide additional signals (via cytokines and direct contact) that are necessary for full B cell activation.
3. Activated B cells undergo clonal expansion, producing many identical copies of themselves.
4. B cells differentiate into plasma cells, which secrete large amounts of antibodies specific to the antigen.
5. Some activated B cells become memory B cells, providing long-term immunity.

Review Questions

Related terms

Antigen:

A molecule or molecular structure recognized by the immune system as foreign, triggering an immune response.

Plasma Cells:

Differentiated B cells that produce and secrete antibodies during an immune response.

Memory Cells: Long-lived immune cells that remember a specific antigen and can mount a faster and stronger response upon re-exposure.