A (aminoacyl) site
Definition
The A (aminoacyl) site on the ribosome is where the incoming aminoacyl-tRNA binds during protein synthesis. It plays a crucial role in translating mRNA into proteins by ensuring that the correct tRNA and its attached amino acid are added to the growing polypeptide chain.
5 Must Know Facts For Your Next Test
- Located on the ribosome, specifically within the large subunit.
- The A site is one of three key sites on the ribosome, along with the P (peptidyl) site and E (exit) site.
- tRNA molecules carrying amino acids enter the ribosome at the A site.
- The codon-anticodon interaction occurs at this site, ensuring proper amino acid addition based on mRNA sequence.
- GTP hydrolysis provides energy for tRNA binding to the A site.
Review Questions
- What function does the A (aminoacyl) site serve in protein synthesis?
- How does tRNA interact with the A site on the ribosome?
- What ensures that the correct amino acid is added at the A site?
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Related terms
P Site: The peptidyl-tRNA binding site where peptide bond formation occurs.
E Site: The exit site where deacylated tRNAs leave the ribosome.
Codon-Anticodon Interaction: Base pairing between mRNA codon and tRNA anticodon that ensures correct amino acid incorporation.
