Dose adjustment in renal impairment refers to the modification of medication dosages based on the kidney function of a patient to prevent drug accumulation and toxicity. This practice is essential because impaired renal function can significantly affect the elimination of drugs from the body, which may lead to adverse effects if standard dosing is continued. Clinicians often rely on kidney function markers, such as creatinine clearance or glomerular filtration rate (GFR), to determine appropriate dose modifications.
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