Newton’s Universal Law of Gravitation states that every particle in the universe attracts every other particle with a force directly proportional to the product of their masses and inversely proportional to the square of the distance between their centers. This law is mathematically expressed as $F = G \frac{m_1 m_2}{r^2}$, where $F$ is the gravitational force, $G$ is the gravitational constant, $m_1$ and $m_2$ are the masses, and $r$ is the distance between their centers.