Notch signaling is a fundamental cell communication pathway that plays a critical role in regulating cell fate decisions, including proliferation, differentiation, and apoptosis. It involves interactions between neighboring cells where the Notch receptor on one cell binds to the Delta or Jagged ligands on an adjacent cell, triggering a cascade of events that influence gene expression and cellular behavior. This pathway is especially important during T cell development, as it helps ensure proper maturation and selection of T cells in the thymus.
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