Oñate's colonization efforts refer to the Spanish expedition led by Juan de Oñate in the late 16th century, aimed at establishing a permanent settlement in what is now New Mexico. These efforts included the founding of Santa Fe, the first capital of New Mexico, and were characterized by the desire to expand Spanish influence, convert Indigenous populations to Christianity, and exploit the region's resources. Oñate's approach was marked by both exploration and conflict with Native American tribes, highlighting the complexities of early colonial interactions.