The Powhatan Wars were a series of conflicts between English colonists in Virginia and the Powhatan Confederacy, a group of Native American tribes led by Chief Powhatan, occurring in the early 17th century. These wars, primarily the First (1609-1614) and Second Powhatan Wars (1622-1632), were significant as they marked the escalation of violence and hostility between European settlers and Indigenous peoples, shaping the future of British colonization in North America.