Syphilis transmission refers to the spread of the sexually transmitted infection syphilis, primarily caused by the bacterium Treponema pallidum. This disease was notably introduced to Europe during the initial encounters between Europeans and Indigenous populations in the Americas, leading to significant health impacts on both groups. The mechanisms of transmission include direct sexual contact and, in some cases, from mother to child during childbirth, illustrating the broader implications of cross-cultural interactions and the spread of diseases in early modern history.