Integration with respect to y refers to the process of calculating the area under a curve or between curves by considering vertical slices of the area, where the integration variable is y instead of x. This method is particularly useful when dealing with functions defined in terms of y, or when the curves are more easily described with respect to the y-axis. It allows for finding areas by integrating functions that may not be easily expressed as functions of x, thus providing a more versatile approach in certain scenarios.