Neurotransmitters

Definition

Neurotransmitters are chemical messengers that transmit signals across synapses from one neuron to another in the nervous system. They play a crucial role in relaying information, influencing various functions such as mood, sleep, and cognition, by binding to receptors on the postsynaptic neuron. Understanding neurotransmitters is vital for grasping the principles of bioelectricity and how cellular engineering can manipulate these processes for therapeutic purposes.

5 Must Know Facts For Your Next Test

1. There are various types of neurotransmitters, including excitatory neurotransmitters like glutamate and inhibitory ones like gamma-aminobutyric acid (GABA).
2. The release of neurotransmitters occurs in response to an action potential reaching the axon terminals of a neuron.
3. Neurotransmitter imbalance can lead to various neurological and psychiatric disorders, highlighting their importance in brain function.
4. Reuptake is a process where neurotransmitters are reabsorbed into the presynaptic neuron after they have performed their function, which helps regulate their levels in the synaptic cleft.
5. Some drugs can mimic or block neurotransmitter action at their receptors, affecting mood and behavior, which is essential for understanding pharmacological treatments.

Review Questions

• How do neurotransmitters contribute to signal transmission between neurons?
  • Neurotransmitters are released from the presynaptic neuron into the synaptic cleft when an action potential reaches the axon terminal. They then bind to receptors on the postsynaptic neuron, leading to either excitation or inhibition of that neuron. This process enables communication between neurons and plays a critical role in influencing behavior and physiological responses.
• Discuss the implications of neurotransmitter imbalances on health and behavior.
  • Neurotransmitter imbalances can significantly affect mental health, leading to conditions such as depression, anxiety, and schizophrenia. For example, low levels of serotonin are often linked to depression, while excessive dopamine activity may be associated with schizophrenia. Understanding these imbalances helps researchers develop targeted treatments, such as selective serotonin reuptake inhibitors (SSRIs), which can help restore normal neurotransmitter levels and improve symptoms.
• Evaluate the impact of pharmacological agents on neurotransmitter systems and their relevance to biomedical engineering.
  • Pharmacological agents can modify neurotransmitter systems by either enhancing or inhibiting their action at synapses. For instance, drugs that increase neurotransmitter availability can improve symptoms of neurological disorders. Biomedical engineering focuses on creating devices or therapies that manipulate these systems, such as brain-computer interfaces or drug delivery systems that target specific neurotransmitter pathways. This intersection illustrates how understanding neurotransmission is essential for developing innovative treatments in medicine.

Related terms

Synapse: A synapse is the junction between two neurons where neurotransmitters are released to transmit signals.

Receptors: Receptors are protein molecules on the surface of neurons that bind to neurotransmitters, initiating a response in the receiving cell.

Action Potential:

An action potential is a rapid rise and fall in voltage across a neuron's membrane, triggered by the binding of neurotransmitters to receptors.