Biological Chemistry I
Okazaki fragments are short sequences of DNA that are synthesized discontinuously on the lagging strand during DNA replication. These fragments are crucial because DNA polymerase can only add nucleotides in a 5' to 3' direction, leading to the creation of these shorter segments that must be later joined together. The existence of Okazaki fragments highlights the semi-discontinuous nature of DNA replication and the coordinated action of various enzymes involved in the process.
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