Biological Chemistry I
Acyl-CoA synthetase is an enzyme that catalyzes the activation of fatty acids by converting them into acyl-CoA, which is essential for the metabolism of lipids. This enzyme plays a critical role in lipid metabolism by facilitating the transport of fatty acids into the mitochondria for beta-oxidation, where they are broken down to generate energy. The reaction involves the formation of a high-energy thioester bond, enabling the fatty acids to enter metabolic pathways efficiently.
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