The GZK Cutoff refers to a theoretical limit on the energy of cosmic rays, specifically protons, due to interactions with cosmic microwave background radiation. This phenomenon suggests that protons with energies above approximately $5 \times 10^{19}$ eV cannot travel beyond about 50-100 million light years from their source before colliding with photons in the cosmic microwave background, resulting in a loss of energy and eventually leading to their absorption.