The main sequence lifetime is the period during which a star fuses hydrogen into helium in its core, representing the longest phase in a star's evolutionary journey. This phase varies significantly depending on the mass of the star, with more massive stars consuming their hydrogen fuel faster and thus having shorter lifetimes, while less massive stars burn their fuel more slowly and can remain on the main sequence for billions of years. The duration of this phase is crucial for understanding stellar evolution and the characteristics of stars on the Hertzsprung-Russell diagram.