Roanoke Colony: Also known as 'The Lost Colony,' it was an English settlement established in present-day North Carolina that mysteriously disappeared around 1590.
Pilgrims: These were English Separatists who sailed on the Mayflower ship and founded Plymouth Colony (Massachusetts) in 1620.
Powhatan Confederacy: A Native American confederation led by Chief Powhatan that interacted with early English settlers at Jamestown, Virginia.