Written by the Fiveable Content Team • Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 exam•Written by the Fiveable Content Team • Last updated September 2025
Definition
When an individual diagnosed with a mental health condition, such as major depressive disorder, does not show significant improvement in symptoms despite trying multiple medications at appropriate doses and durations.
Related terms
Treatment-Resistant Depression (TRD): TRD refers specifically to major depressive disorder that doesn't respond adequately to several trials of antidepressant medications.
Augmentation Therapy: Augmentation therapy involves adding another medication or treatment alongside existing antidepressant medication(s) to enhance their effectiveness for individuals who are resistant to traditional treatments.
ECT is a procedure that involves passing electric currents through the brain under anesthesia. It can be effective for individuals who haven't responded well to medications or other forms of treatment.