Written by the Fiveable Content Team โข Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 examโขWritten by the Fiveable Content Team โข Last updated September 2025
Definition
Capsaicin is a compound found in hot peppers that activates the TRPV1 receptor, leading to the sensation of heat or physical abrasiveness. It stimulates nerve endings, resulting in the perception of pain and a release of endorphins.
Related terms
TRPV1 receptor: This is a receptor found on sensory neurons that responds to capsaicin and other stimuli related to temperature and pain.
Sensation of heat: The perception of warmth or high temperature experienced when capsaicin binds to the TRPV1 receptor.
Physical abrasiveness: The feeling of irritation or roughness caused by capsaicin activating the TRPV1 receptor, even though no physical harm is occurring.