💀anatomy and physiology i review

Synaptic cleft

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

The synaptic cleft is a tiny gap between the axon terminal of one neuron and the dendrite or cell body of another neuron or muscle cell. It facilitates the transfer of chemical signals across neurons or between neurons and muscle cells.

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