Principal cell

Definition

Principal cells are specialized cells located in the collecting ducts of the kidneys, primarily involved in the reabsorption of water and sodium ions and the secretion of potassium ions. They play a critical role in regulating the body's electrolyte balance and blood pressure.

Related terms

Collecting ducts: These are tubules within the kidneys that receive urine from several nephrons and play a key role in concentrating urine and maintaining water-electrolyte balance.

Tubular reabsorption: This is the process by which solutes and water are removed from tubular fluid (pre-urine) in the kidney nephrons and returned to the blood.

Electrolyte balance: The maintenance of correct concentrations of electrolytes (like sodium, potassium, and chloride) in the body fluids, crucial for normal function of cells and organs