Intrinsic factor

Definition

Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach lining that is essential for the absorption of vitamin B12 in the small intestine. Without intrinsic factor, vitamin B12 cannot be absorbed, leading to potential deficiencies.

Related terms

Parietal Cells: Cells located in the lining of the stomach that produce hydrochloric acid and intrinsic factor.

Vitamin B12 Absorption: The process by which vitamin B12, bound to intrinsic factor, is absorbed through the walls of the ileum in the small intestine.

Pernicious Anemia: A condition caused by vitamin B12 deficiency often due to lack of intrinsic factor production, leading to reduced red blood cell formation