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🫀anatomy and physiology ii review

Hypothalamic-pituitary-gonadal (hpg) axis

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

The hypothalamic-pituitary-gonadal (hpg) axis is a complex set of interactions between the hypothalamus, pituitary gland, and gonads that regulates reproductive function and hormone production. This axis plays a vital role in controlling the secretion of sex hormones such as testosterone, estrogen, and progesterone, influencing not only reproduction but also secondary sexual characteristics and various bodily functions.

5 Must Know Facts For Your Next Test

  1. The hpg axis starts with the hypothalamus releasing GnRH, which then stimulates the anterior pituitary to release LH and FSH.
  2. LH and FSH act on the gonads (ovaries in females, testes in males) to stimulate the production of sex hormones.
  3. The levels of sex hormones then provide feedback to both the hypothalamus and pituitary gland to regulate further hormone secretion.
  4. Disruptions in the hpg axis can lead to disorders such as hypogonadism, polycystic ovary syndrome (PCOS), and other reproductive issues.
  5. The hpg axis is crucial not only for reproduction but also influences metabolic processes, bone health, and mood regulation.

Review Questions

  • Explain how the hypothalamic-pituitary-gonadal axis regulates hormone levels in the body.
    • The hpg axis begins with the hypothalamus secreting GnRH, which prompts the pituitary gland to release LH and FSH. These hormones act on the gonads, stimulating them to produce sex hormones like testosterone and estrogen. The increased levels of these hormones provide negative feedback to both the hypothalamus and pituitary, helping maintain hormonal balance within the body.
  • Discuss the roles of LH and FSH in male and female reproductive health as part of the hpg axis.
    • In males, LH stimulates testosterone production from Leydig cells in the testes, while FSH supports sperm maturation in Sertoli cells. In females, LH triggers ovulation and supports corpus luteum function, while FSH is responsible for follicle development and estrogen production. Both hormones are critical for normal reproductive functions and fertility, highlighting their importance within the hpg axis.
  • Evaluate how disruptions in the hpg axis can affect overall health and contribute to reproductive disorders.
    • Disruptions in the hpg axis can lead to insufficient or excessive production of sex hormones, resulting in conditions such as hypogonadism or polycystic ovary syndrome (PCOS). These hormonal imbalances can cause a range of health issues, including infertility, metabolic problems, and mood disorders. Understanding these effects underscores the importance of maintaining a healthy hpg axis for overall well-being and reproductive health.