Significant weight loss refers to an individual losing a substantial amount of body weight, typically defined as 10% or more of their starting body weight, within a relatively short period. This term is particularly relevant in understanding eating disorders, where drastic changes in weight can be a key indicator of underlying psychological issues such as distorted body image and unhealthy eating behaviors. It is often associated with severe health risks and can be a critical diagnostic criterion for conditions related to inadequate nutritional intake.