Einstein's Mass-Energy Equivalence: The theory that mass and energy are different forms of the same thing, and can be converted into one another according to the equation $E = mc^2$, where $E$ is energy, $m$ is mass, and $c$ is the speed of light.
Nuclear Binding Energy: The energy required to break apart a nucleus into its individual protons and neutrons. This energy is released when nuclei are formed, and is the source of energy in nuclear reactions.
Nuclear Fission and Fusion: Nuclear reactions in which heavy nuclei are split apart (fission) or light nuclei are combined (fusion), resulting in the release or absorption of large amounts of energy due to changes in mass-energy.