Ozone layer depletion refers to the gradual thinning of the ozone layer, which is located in the Earth's stratosphere and absorbs the majority of the sun's harmful ultraviolet (UV) radiation. This phenomenon is primarily caused by human-made chemicals, particularly chlorofluorocarbons (CFCs), which break down ozone molecules, leading to increased UV radiation reaching the Earth's surface. The depletion of the ozone layer is critical as it impacts ecosystems, human health, and contributes to climate change.