Animals maintain homeostasis by regulating internal conditions, although the conditions and ranges vary among species. Comparative physiology asks how different species manage factors such as temperature, pH, water and ion levels.
For temperature, ectotherms like lizards rely on outside heat, and endotherms like birds and mammals generate heat by metabolism. Many endotherms can stay active in the cold, but some reduce their activity or enter hibernation. At rest, endotherms generally need more energy than ectotherms of the same size. Countercurrent heat exchange in a penguin's flipper lets warm outgoing blood heat cold returning blood, so little heat escapes.
For water balance, a freshwater fish is saltier than its surroundings, so water rushes in; it makes lots of dilute urine and pumps ions in through its gills. A marine bony fish is less salty than seawater, so it loses water, drinks seawater and pumps salt out through its gills.
Insects and most mollusks have open circulation, where hemolymph bathes tissues directly. Vertebrates and annelids have closed circulation in vessels. Most fish have a heart with one atrium and one ventricle, while birds and mammals have four chambers that fully separate oxygenated and deoxygenated blood.
Gas exchange surfaces are thin, moist and large. Fish gills use countercurrent exchange, human lungs have about 300 million alveoli (roughly 70 m²), and insect tracheae deliver air straight to cells.
Worked example. Water at about 20°C holds roughly 8 mg of dissolved O₂ per liter. If gills extract 80%, a fish gets 0.80×8=6.4 mg per liter. To take in 32 mg of O₂, it must pass 32÷6.4=5 liters of water over its gills.
- Homeostasis: Keeping internal conditions like temperature, pH and water balance within the range cells need.
- Osmoregulation: Controlling water and solute balance so body fluids don't become too dilute or too concentrated.
- Countercurrent exchange: Two fluids flowing in opposite directions so a gradient is kept along the whole surface, used for oxygen in gills and heat in limbs.
- Closed circulatory system: A system where blood stays within the heart and blood vessels. This arrangement can maintain higher pressure and deliver blood faster than an open system.
Check yourself: How can an insect's gas exchange system limit its body size? (Answer: Oxygen moves through tracheal tubes and diffuses to nearby cells. As an insect grows, supplying its inner tissues with enough oxygen becomes harder, which can limit body size.)