The Milesian School, founded by Thales of Miletus, marked the birth of Western philosophy in 6th century BCE Greece. These thinkers sought to explain the natural world through reason and observation, moving away from mythological explanations and towards a more scientific approach. Key figures like Thales, Anaximander, and Anaximenes proposed different fundamental substances as the origin of all things. Their ideas about the cosmos, natural phenomena, and the nature of matter laid the groundwork for later philosophical and scientific developments in ancient Greece and beyond.