Negated quantifiers are logical constructs that express the denial of a quantified statement. When a universal quantifier (e.g., 'for all') is negated, it indicates that there exists at least one instance for which the statement does not hold true. Conversely, negating an existential quantifier (e.g., 'there exists') asserts that no instances fulfill the criteria specified by the original statement. Understanding these negated forms is crucial for applying inference rules effectively, as they allow for the manipulation of logical statements to derive valid conclusions.