U.S. international relations refers to the complex and multifaceted interactions between the United States and other nations, encompassing diplomacy, trade, military alliances, and cultural exchanges. During times of economic crisis, such as the Great Depression, these relations were significantly impacted as the U.S. sought to stabilize its economy while addressing global economic challenges. This period marked a shift in how the U.S. engaged with the world, emphasizing both isolationist tendencies and the need for international cooperation.