💀anatomy and physiology i review

Clonal selection

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Clonal selection is a fundamental mechanism in the immune response where a specific antigen selectively binds to and activates only those lymphocytes (B cells and T cells) bearing receptors specific for the antigen. As a result, these selected cells proliferate and differentiate into a clone of effector cells that target the antigen.

Course connection

Topic 21.3: 21.3 The Adaptive Immune Response: T lymphocytes and Their Functional Types

Unit 21

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