Written by the Fiveable Content Team • Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 exam•Written by the Fiveable Content Team • Last updated September 2025
Definition
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.
Related terms
Coenzyme: This is like rechargeable batteries. It’s a type of cofactor that are organic molecules and can be reused in multiple reactions.
Prosthetic Group: This would be like built-in, non-removable batteries. They’re permanently bound to their enzymes.
Apoenzyme/Holoenzyme: These are like your remote control car without/with batteries. Apoenzyme is inactive enzyme without its cofactor while holoenzyme is active with its cofactor.