Written by the Fiveable Content Team โข Last updated September 2025
Verified for the 2026 exam
Verified for the 2026 examโขWritten by the Fiveable Content Team โข Last updated September 2025
Definition
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.
Related terms
Coenzyme: This is like rechargeable batteries. Itโs a type of cofactor that are organic molecules and can be reused in multiple reactions.
Prosthetic Group: This would be like built-in, non-removable batteries. Theyโre permanently bound to their enzymes.
Apoenzyme/Holoenzyme: These are like your remote control car without/with batteries. Apoenzyme is inactive enzyme without its cofactor while holoenzyme is active with its cofactor.